Efficacy of Postexposure Therapy against Glanders in Mice
نویسندگان
چکیده
منابع مشابه
Efficacy of postexposure therapy against glanders in mice.
Burkholderia mallei, the causative agent of glanders, is a CDC Tier 1 Select Agent for which there is no preventive vaccine and antibiotic therapy is difficult. In this study, we show that a combination of vaccination using killed cellular vaccine and therapy using moxifloxacin, azithromycin, or sulfamethoxazole-trimethoprim can protect BALB/c mice from lethal infection even when given 5 days a...
متن کاملThe Efficacy of Post-Exposure Therapy Against Glanders in Mice
13 Burkholderia mallei, the causative agent of glanders, is a CDC Tier 1 Select Agent for 14 which there is no preventive vaccine and antibiotic therapy is difficult. In this study, we 15 show that a combination of vaccination using killed cellular vaccine and therapy using 16 moxifloxacin, azithromycin, or sulfamethoxazole / trimethoprim can protect BALB/c 17 mice from lethal infection even wh...
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Burkholderia mallei is an obligate mammalian pathogen that causes the zoonotic disease glanders. Two live attenuated B. mallei strains, a capsule mutant and a branched-chain amino acid auxotroph, were evaluated for use as vaccines against aerosol-initiated glanders in mice. Animals were aerogenically vaccinated and serum samples were obtained before aerosol challenge with a high-dose (>300 time...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2015
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.04801-14